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血管緊張素轉(zhuǎn)換酶2抗體
  • 產(chǎn)品貨號：
    BN41892R
  • 中文名稱：
    血管緊張素轉(zhuǎn)換酶2抗體
  • 英文名稱：
    Rabbit anti-ACE2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41892R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ELISA

  • BN41892R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ELISA

  • BN41892R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ELISA

產(chǎn)品描述

英文名稱ACE2
中文名稱血管緊張素轉(zhuǎn)換酶2抗體
別    名ACE-2; ACE 2; Angiotensin converting enzyme 2; ACE related carboxypeptidase; ACEH; Angiotensin converting enzyme homolog; Angiotensin converting enzyme like protein; Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2; Angiotensin I converting enzyme 2; DKFZP434A014; EC 3.4.17; OTTHUMP00000022963; angiotensin-converting enzyme 2 precursor; ACE2_HUMAN; Angiotensin-converting enzyme 2; ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; Metalloprotease MPROT15; Processed angiotensin-converting enzyme 2.  
研究領(lǐng)域細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:400-800 IHC-F=1:400-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量100/120kDa
細胞定位細胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ACE2: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008].

Function:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Subunit:
Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein.

Subcellular Location:
Processed angiotensin-converting enzyme 2: Secreted.
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system.

Post-translational modifications:
N-glycosylation on Asn-90 may limit SARS infectivity.
Proteolytic cleavage by ADAM17 generates a secreted form.

Similarity:
Belongs to the peptidase M2 family.

SWISS:
Q9BYF1

Gene ID:
59272

Database links:

Entrez Gene: 59272 Human

Entrez Gene: 70008 Mouse

Entrez Gene: 302668 Rat

Omim: 300335 Human

SwissProt: Q9BYF1 Human

SwissProt: Q8R0I0 Mouse

SwissProt: Q5EGZ1 Rat

Unigene: 178098 Human

Unigene: 13451 Mouse

Unigene: 129779 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解（Synthesis and Degradation）
ACE-2的分布范圍比較局限，ACE2主要在心臟、腎臟、睪丸中表達顯著， 近來人們發(fā)現(xiàn)ACE2也分布在胃腸道、腦和肺臟中。
有關(guān)學(xué)者在研究心臟和腎臟中發(fā)現(xiàn)，ACE2在心肌缺血、腎功能衰竭、動脈粥樣硬化和糖尿病并發(fā)癥中，ACE2對血管緊張素產(chǎn)生和降解過程中有一定的生理作用。
特別是對ACE2在具有生理活性的-活性肽產(chǎn)生過程中的作用更值得進一步研究。 ACE2的發(fā)現(xiàn)為心血管病和腎臟病研究開辟了新天地，并提供了新的治療靶點，可能導(dǎo)致未來心血管疾病治療策略的改變。