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產(chǎn)品規(guī)格
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BN41899R-50ul
50ul
￥1486.00
交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,Flow-Cyt,ELISA
BN41899R-100ul
100ul
￥2360.00
交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,Flow-Cyt,ELISA
BN41899R-200ul
200ul
￥3490.00
交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | BNIP3 |
| 中文名稱 | 促凋亡調(diào)節(jié)蛋白BNIP3抗體 |
| 別 名 | BCL2 Adenovirus E1B 19kDa Interacting Protein 3; BCL2/adenovirus E1B 19 kDa protein interacting protein 3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BNIP 3; BNIP3_HUMAN; NIP 3; NIP3. |
| 研究領(lǐng)域 | 腫瘤 心血管 免疫學(xué) 細(xì)胞凋亡 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=2ug/Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BNIP3:101-194/194 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Apoptosis-inducing protein that, which can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Function: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. Subunit: Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Also can interact with adenovirus E1B 19 kDa protein or Epstein-Barr virus BHRF1. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Subcellular Location: Mitochondrion. Mitochondrion membrane. Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Similarity: Belongs to the NIP3 family. SWISS: Q12983 Gene ID: 664 Database links: Entrez Gene: 664 Human Entrez Gene: 12176 Mouse Omim: 603293 Human SwissProt: Q12983 Human SwissProt: O55003 Mouse Unigene: 144873 Human Unigene: 378890 Mouse Unigene: 2060 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. BNIP3蛋白在缺氧條件下可誘導(dǎo)細(xì)胞發(fā)生細(xì)胞凋亡。BNIP3促細(xì)胞凋亡線粒體途徑根據(jù)有無(wú)caspase的參與而具有不同的作用機(jī)制，也是研究的熱點(diǎn)。BNIP3還可誘導(dǎo)細(xì)胞自噬。BNIP3全稱為Bcl2/腺病毒E1B19kD相互作用蛋白3。(Bcl2/adenovirusE1B19kDainteractingprotein3，BNIP3)，是新近發(fā)現(xiàn)的BH3only亞家族成員之一，也是低氧敏感的凋亡基因。在化學(xué)性低氧誘導(dǎo)細(xì)胞凋亡的過(guò)程中，ATP是BNIP3導(dǎo)致細(xì)胞凋亡的關(guān)鍵性因素之一。單獨(dú)ATP下降不誘導(dǎo)細(xì)胞凋亡，但ATP下降到一定程度能促進(jìn)BNIP3向線粒體轉(zhuǎn)位，從而誘導(dǎo)了BNIP3相關(guān)的凋亡。這可能是低氧誘導(dǎo)BNIP3表達(dá)導(dǎo)致細(xì)胞凋亡的重要機(jī)制之一。 |
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