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胞質(zhì)接頭蛋白Keap1
  • 產(chǎn)品貨號(hào):
    BN41916R
  • 中文名稱:
    胞質(zhì)接頭蛋白Keap1
  • 英文名稱:
    Rabbit anti-KEAP1 Polyclonal antibody
  • 品牌:
    Biorigin
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  • BN41916R-50ul

    50ul

    ¥1486.00

    交叉反應(yīng):Rat,Mouse,Human(predicted:Rabbit,Cow,Pig,Dog) 推薦應(yīng)用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41916R-100ul

    100ul

    ¥2360.00

    交叉反應(yīng):Rat,Mouse,Human(predicted:Rabbit,Cow,Pig,Dog) 推薦應(yīng)用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41916R-200ul

    200ul

    ¥3490.00

    交叉反應(yīng):Rat,Mouse,Human(predicted:Rabbit,Cow,Pig,Dog) 推薦應(yīng)用:WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱KEAP1
中文名稱胞質(zhì)接頭蛋白Keap1
別    名Cytosolic inhibitor of Nrf2; INrf 2; INrf2; Keap 1; KEAP1; KEAP1_HUMAN; Kelch like ECH associated protein 1; Kelch like protein 19; Kelch-like ECH-associated protein 1; Kelch-like protein 19; KIAA0132; KLHL 19; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454.  


研究領(lǐng)域腫瘤  細(xì)胞生物  發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量69kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human KEAP1:21-120/624 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Subunit:
Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1.

Subcellular Location:
Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.

Tissue Specificity:
Broadly expressed, with highest levels in skeletal muscle.

Similarity:
Contains 1 BACK (BTB/Kelch associated) domain.
Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.

SWISS:
Q14145

Gene ID:
9817

Database links:

Entrez Gene: 532791 Cow

Entrez Gene: 476713 Dog

Entrez Gene: 9817 Human

Entrez Gene: 50868 Mouse

Entrez Gene: 100136900 Pig

Entrez Gene: 117519 Rat

Entrez Gene: 321837 Zebrafish

Omim: 606016 Human

SwissProt: Q14145 Human

SwissProt: Q9Z2X8 Mouse

SwissProt: Q684M4 Pig

SwissProt: P57790 Rat

Unigene: 465870 Human

Unigene: 248266 Mouse

Unigene: 23467 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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