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熱休克蛋白71抗體
  • 產(chǎn)品貨號(hào)：
    BN41920R
  • 中文名稱：
    熱休克蛋白71抗體
  • 英文名稱：
    Rabbit anti-Hsc70 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41920R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat,Cow(predicted:Chicken,Pig,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41920R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat,Cow(predicted:Chicken,Pig,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41920R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat,Cow(predicted:Chicken,Pig,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Hsc70
中文名稱熱休克蛋白71抗體
別    名2410008N15Rik; Constitutive heat shock protein 70; Heat shock 70 kDa protein 8; Heat shock 70kD protein 10; Heat shock 70kD protein 8; Heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; Heat shock cognate protein 54; Heat shock cognate protein 71 kDa; Heat shock protein 8; Heat shock protein A8; Heat-shock70-KD protein 10, formerly; HSC54; HSC71; Hsc73; HSP71; HSP73; HSP7C_HUMAN; HSPA10; HSPA8; LAP1; Lipopolysaccharide associated protein 1; LPS associated protein 1; LPS associated protein; MGC102007; MGC106514; MGC114311; MGC118485; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; NIP71； HSC 70； HSC-70.  





研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, Cow,  (predicted: Chicken, Pig, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量71kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HSP71:501-600/646 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Function:
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.

Subunit:
Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7 (By similarity). Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation.

Subcellular Location:
Cytoplasm. Melanosome.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. ISGylated.

Similarity:
Belongs to the heat shock protein 70 family.

SWISS:
P11142

Gene ID:
3312

Database links:

Entrez Gene: 3312 Human

Entrez Gene: 15481 Mouse

Entrez Gene: 24468 Rat

Omim: 600816 Human

SwissProt: P11142 Human

SwissProt: P63017 Mouse

SwissProt: P63018 Rat

Unigene: 180414 Human

Unigene: 290774 Mouse

Unigene: 336743 Mouse

Unigene: 351377 Mouse

Unigene: 412745 Mouse

Unigene: 120392 Rat

Unigene: 201298 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.