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過(guò)氧化物酶體增殖物激活受體γ輔激活子1α+β抗體
  • 產(chǎn)品貨號(hào)：
    BN41961R
  • 中文名稱(chēng)：
    過(guò)氧化物酶體增殖物激活受體γ輔激活子1α+β抗體
  • 英文名稱(chēng)：
    Rabbit anti-PGC1 alpha + beta Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41961R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Rat,Pig(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41961R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat,Pig(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41961R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat,Pig(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱(chēng)PGC1 alpha + beta
中文名稱(chēng)過(guò)氧化物酶體增殖物激活受體γ輔激活子1α+β抗體
別    名LEM6; Ligand effect modulator 6; PERC; Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; Peroxisome proliferative activated receptor, gamma, coactivator 1; Peroxisome proliferator activated receptor gamma coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC 1 (alpha); PGC 1 alpha; PGC 1v; PGC-1(beta); PGC-1-alpha; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC1; PGC1(alpha); PGC1A; PGC1v; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1; PPAR gamma coactivator variant form; PPAR gamma coactivator-1beta; PPAR-gamma coactivator 1-alpha; PPAR-gamma coactivator 1-beta; PPARGC 1 alpha; PPARGC-1-alpha; PPARGC-1-beta; PPARGC1; PPARGC1A; Ppargc1b; PRGC1_HUMAN; PRGC2_HUMAN.  







研究領(lǐng)域心血管  細(xì)胞生物  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  糖尿病  表觀遺傳學(xué)  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Rat, Pig,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88/113kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PGC1 alpha + beta:151-250/798 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq].

Function:
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis.

Subunit:
Binds MYBBP1A, which inhibits transcriptional activation by this protein. Interacts with PRDM16. Interacts with LRPPRC. Homooligomer. Interacts with LPIN1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.

Post-translational modifications:
Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.

Similarity:
Contains 1 RRM (RNA recognition motif) domain.

SWISS:
Q9UBK2

Gene ID:
10891

Database links:

Entrez Gene: 10891 Human

Entrez Gene: 133522 Human

Entrez Gene: 170826 Mouse

Entrez Gene: 19017 Mouse

Entrez Gene: 291567 Rat

Entrez Gene: 83516 Rat

Omim: 604517 Human

Omim: 608886 Human

SwissProt: Q86YN6 Human

SwissProt: Q9UBK2 Human

SwissProt: 415302 Mouse

SwissProt: O70343 Mouse

SwissProt: Q8VHJ7 Mouse

SwissProt: Q811R2 Rat

SwissProt: Q9QYK2 Rat

Unigene: 483816 Human

Unigene: 527078 Human

Unigene: 163382 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.