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神經(jīng)細(xì)胞死亡誘導(dǎo)蛋白激酶抗體
  • 產(chǎn)品貨號(hào)：
    BN41962R
  • 中文名稱(chēng)：
    神經(jīng)細(xì)胞死亡誘導(dǎo)蛋白激酶抗體
  • 英文名稱(chēng)：
    Rabbit anti-TRIB3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41962R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken,Mouse) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41962R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken,Mouse) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41962R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Chicken,Mouse) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱(chēng)TRIB3
中文名稱(chēng)神經(jīng)細(xì)胞死亡誘導(dǎo)蛋白激酶抗體
別    名C20orf97; Neuronal cell death inducible putative kinase; Neuronal cell death-inducible putative kinase; NIPK; p65 interacting inhibitor of NF-kappaB; p65-interacting inhibitor of NF-kappa-B; SINK; SKIP 3; SKIP3; TRB 3; TRB-3; TRB3; TRIB 3; Trib3; TRIB3_HUMAN; Tribbles homolog 3; Tribbles3.  
研究領(lǐng)域心血管  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  細(xì)胞周期蛋白  糖尿病  細(xì)胞分化  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量40kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TRIB3/p65 interacting inhibitor of NF-kappaB:201-300/358 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

Function:
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.

Subunit:
Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, including testis, ovary, small intestine, colon, leukocyte, heart, brain, placenta, lung, skeletal muscle, and kidney.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
Contains 1 protein kinase domain.

SWISS:
Q96RU7

Gene ID:
57761

Database links:

Entrez Gene: 57761 Human

Omim: 607898 Human

SwissProt: Q96RU7 Human

Unigene: 516826 Human

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications