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細(xì)胞角蛋白19單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN41987M
  • 中文名稱：
    細(xì)胞角蛋白19單克隆抗體
  • 英文名稱：
    Mouse anti-Cytokeratin 19 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN41987M-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN41987M-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱Cytokeratin 19
中文名稱細(xì)胞角蛋白19單克隆抗體
別    名40 kDa keratin intermediate filament; CK 19; ck19; CK19; CK-19; KRT19; Cytokeratin19; Cytokeratin-19; k19; k1cs; Keratin 19; Keratin-19; Keratin type I 40 kD; Keratin type i 40kD; Keratin type I cytoskeletal 19; krt19; mgc15366; K1C19_HUMAN; Keratin, type I cytoskeletal 19; Keratin, type I, 40 kd  



研究領(lǐng)域腫瘤  細(xì)胞生物  干細(xì)胞  
抗體來源Mouse
克隆類型Monoclonal
克 隆 號(hào)10H7
交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Cytokeratin 19: 
亞    型IgG
純化方法affinity purified by Protein G
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Function:
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Subunit:
Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.

Tissue Specificity:
Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P08727

Gene ID:
3880

Database links:

Entrez Gene: 3880 Human

Entrez Gene: 16669 Mouse

Omim: 148020 Human

SwissProt: P08727 Human

SwissProt: P19001 Mouse

Unigene: 654568 Human

Unigene: 439699 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

結(jié)構(gòu)蛋白（Structural Proteins）
CK-19細(xì)胞角蛋白-19(又稱CYFRa21-1)主要用于腫瘤方面的研究，近年來大多用于消化系統(tǒng)惡性腫瘤的鑒別，有學(xué)者認(rèn)為：CK-19在胰腺干細(xì)胞分化過程中有細(xì)胞角蛋白19的表達(dá)，把細(xì)胞角蛋白19作為胰腺干細(xì)胞的標(biāo)志物。陽性部位：主要在胞漿。