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神經(jīng)生長因子β重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42128R
  • 中文名稱：
    神經(jīng)生長因子β重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-NGF Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN42128R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Zebrafish) 推薦應(yīng)用：WB

  • BN42128R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Zebrafish) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱NGF
中文名稱神經(jīng)生長因子β重組兔單克隆抗體
別    名Beta nerve growth factor; NGF-beta; Beta nerve growth factor precursor; Beta NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor beta; Nerve growth factor beta polypeptide; Nerve growth factor beta subunit; NGF B; NID67; NGF beta; NGF-B; NGF_HUMAN.  
研究領(lǐng)域發(fā)育生物學(xué)  神經(jīng)生物學(xué)  細(xì)胞因子  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號11G1
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Zebrafish, )
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量13/32kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human NGF: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

DISEASE:
Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.

Similarity:
Belongs to the NGF-beta family.

SWISS:
P01138

Gene ID:
4803

Database links:

Entrez Gene: 4803 Human

Entrez Gene: 18049 Mouse

Entrez Gene: 310738 Rat

Omim: 162030 Human

SwissProt: P01138 Human

SwissProt: P01139 Mouse

SwissProt: P25427 Rat

Unigene: 2561 Human

Unigene: 1259 Mouse

Unigene: 22168 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
















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