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胰島素促進(jìn)因子重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42157R
  • 中文名稱：
    胰島素促進(jìn)因子重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-PDX1 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

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  • BN42157R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN42157R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱PDX1
中文名稱胰島素促進(jìn)因子重組兔單克隆抗體
別    名Glucose sensitive factor; Glucose-sensitive factor; GSF; IDX 1; IDX-1; IDX1; Insulin promoter factor 1; insulin promoter factor 1 homeodomain transcription factor; insulin upstream factor 1; IPF 1; IPF-1; IPF1; Islet/duodenum homeobox 1; Islet/duodenum homeobox-1; IUF 1; IUF-1; IUF1; MODY4; Pancreas/duodenum homeobox 1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox P; PDX 1; PDX-1; PDX1; PDX1_HUMAN; Somatostatin transactivating factor 1; Somatostatin-transactivating factor 1; STF 1; STF-1; STF1.  
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  內(nèi)分泌病  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號34A1
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:500 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量30kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Lyophilized or Liquid
濃    度1mg/ml
免 疫 原Recombinant human PDX1 protein: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017]

Function:
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Subunit:
Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with SPOP. Interacts with the methyltransferase SETD7.

Subcellular Location:
Nucleus.

Tissue Specificity:
Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).

Post-translational modifications:
Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.

DISEASE:
Defects in PDX1 are a cause of pancreatic agenesis (PAC)[MIM:260370]. This autosomal recessive disorder is characterized by absence or hypoplasia of pancreas, leading to early-onset insulin-dependent diabetes mellitus. This was found in a frameshift mutation that produces a truncated protein and results in a second initiation that produces a second protein that act as a dominant negative mutant.
Defects in PDX1 are a cause of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.
Defects in PDX1 are the cause of maturity-onset diabetes of the young type 4 (MODY4) [MIM:606392]; also symbolized MODY-4. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Similarity:
Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.
Contains 1 homeobox DNA-binding domain.

SWISS:
P52945

Gene ID:
3651

Database links:

Entrez Gene: 538927 Cow

Entrez Gene: 493994 Dog

Entrez Gene: 3651 Human

Entrez Gene: 18609 Mouse

Entrez Gene: 29535 Rat

Omim: 600733 Human

SwissProt: P52945 Human

SwissProt: P52946 Mouse

SwissProt: P52947 Rat

Unigene: 32938 Human

Unigene: 389714 Mouse

Unigene: 54603 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.